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ba0005p182 | Cell biology: osteoclasts and bone resorption | ECTS2016

Human dendritic cell-derived osteoclasts have the ability for both bone absorption and T cell stimulation

Narisawa Manabu , Kubo Satoshi , Nakayamada Shingo , Zhao Jidong , Sakata Kei , Okada Yosuke , Yamaoka Kunihiro , Tanaka Yoshiya

Objective: It is well known that monocytes differentiate into osteoclasts. However, we found that human dendritic cells (DCs) also differentiate to osteoclast-like cells and assessed the role of dendritic cell-derived osteoclast (DC-OC) in pathological processes of inflammatory diseases such as rheumatoid arthritis (RA).Methods: DC-OCs were differentiated from human monocyte-derived DCs in vitro. The function of DC-OCs was compared to human mono...

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ba0005p425 | Other diseases of bone and mineral metabolism | ECTS2016

IL-6/STAT3 pathway is critically involved in vascular calcification via histone modification of the RUNX2 promoter in vascular smooth muscle cells

Kurozumi Akira , Nakano Kazuhisa , Yamagata Kaoru , Okada Yosuke , Nakayamada Shingo , Tanaka Yoshiya

Objective: Both inflammation and vascular calcification have been known as independent risk factors of cardiovascular events. However, the induction mechanism of vascular calcification by inflammation is still unclear. We here assessed the molecular effects of pro-inflammatory cytokines on vascular smooth muscle cell (VSMC) calcification.Methods: VSMCs from human aorta cultured in osteoblast induction medium (OIM) and stimulated by pro-inflammatory cytok...

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Bone Abstracts

Human dendritic cell-derived osteoclasts have the ability for both bone absorption and T cell stimulation

IL-6/STAT3 pathway is critically involved in vascular calcification via histone modification of the RUNX2 promoter in vascular smooth muscle cells

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